Haemostatic effects of colloids
	n all semi-synthetic colloid solutions produce some impairment of haemostasis n Primarily due to haemodilution of clotting factors n Gelatins (e.g. Haemaccel & Gelofusin) - least impact on haemostasis n Dextrans - more significant haemostatic derangements - max dose 1.5g/kg to avoid risk bleeding n lowMW dextrans increase microvascular flow & have specific effects - FVIII activity reduced, plasminogen activation and fibrinolysis increased, clot strength reduced & platelet function impaired