Activated Platelets
n Activated by small amount of thrombin
generated by TF-VIIa complex
n Activation leads to negatively charged
phospholipids being exposed on platelet surface
n Forms the platform for augmentation of
coagulation
n IXa generated binds to platelet surface and
with VIIIa forms Xase complex
n Xase complex leads to generation of
increased thrombin Thrombin Burst”