Impaired Haemostasis in Massive Bleeding
		n Multifactorial n Dilution of platelets and coagulation factors following transfusion and volume expanders n Loss of haemostatic factors n Consumption in clot formation n Disseminated intravascular coagulation (DIC) n Hypothermia n Acidosis n Platelet dysfunction n Haemostatic impairment due to semisynthetic colloids n All these lead to impaired thrombin generation